Therapeutic Specialties Archives

Publication

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

The aim of this study was to model the in vivo kinetic consequences of mechanism-based…

webdev2006 年 11 月 1 日

Publication

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…

webdev2006 年 9 月 1 日

Publication

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…

webdev2006 年 5 月 1 日

Publication

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

The aim of this study was to develop a pain relief model for a cyclooxygenase…

webdev2006 年 4 月 1 日

Publication

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

A diversity of equations is available for the estimation of liver volume (LV), derived from…

webdev2005 年 12 月 1 日

Publication

Model-based Development of Gemcabene, a New Lipid-altering Agent

The purpose of this study was to evaluate the value of model-based, quantitative decision making…

webdev2005 年 10 月 7 日

Publication

Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model

Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…

webdev2005 年 9 月 1 日

Publication

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation

A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…

webdev2005 年 9 月 1 日

Publication

Modelling Approaches to Dose Estimation in Children

Most of the drugs on the market are originally developed for adults and dosage selection…

webdev2005 年 6 月 1 日

Publication

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…

webdev2005 年 1 月 1 日

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Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

Model-based Development of Gemcabene, a New Lipid-altering Agent

Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model

Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation

Modelling Approaches to Dose Estimation in Children

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

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