Certara Products - Simcyp Archives | 第 20 页，共 21 页

Publication

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

The development of in vitro-in vivo extrapolation (IVIVE), a 'bottom-up' approach, to predict pharmacokinetic parameters…

webdev2013 年 3 月 1 日

Publication

Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies

Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the…

webdev2013 年 2 月 1 日

Publication

Optimal Sampling Times for a Drug and Its Metabolite Using Simcyp Simulations as Prior Information

Since 2007, it is mandatory for the pharmaceutical companies to submit a Pediatric Investigation Plan…

webdev2013 年 1 月 1 日

Publication

Application of PBPK Modeling to Predict Monoclonal Antibody Disposition in Plasma and Tissues in Mouse Models of Human Colorectal Cancer

This investigation evaluated the utility of a physiologically based pharmacokinetic (PBPK) model, which incorporates model…

webdev2012 年 12 月 1 日

Publication

A Pregnancy Physiologically-based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4, and CYP2D6

Pregnant women are usually not part of the traditional drug development program. Pregnancy is associated…

webdev2012 年 10 月 9 日

Publication

Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions

To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI)…

webdev2012 年 10 月 1 日

Publication

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

The physiological changes that occur in the maternal body and the placental-foetal unit during pregnancy…

webdev2012 年 7 月 1 日

Publication

From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example

A case example is presented in which the physiologically based modeling approach has been used…

webdev2012 年 3 月 1 日

刊物

Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs?

In 2005, a survey compared a number of commercial PBPK software available at the time,…

webdev2012 年 3 月 1 日

Publication

Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events

Positive allosteric modulators ('potentiators') of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) have been shown to display…

webdev2012 年 3 月 1 日

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Certara Products – Simcyp

Predicting Drug-drug Interactions: Application of Physiologically-based Pharmacokinetic Models Under a Systems Biology Approach

Pharmacokinetics, Pharmacodynamics, Physiologically-based Pharmacokinetic Modeling of Monoclonal Antibodies

Optimal Sampling Times for a Drug and Its Metabolite Using Simcyp Simulations as Prior Information

Application of PBPK Modeling to Predict Monoclonal Antibody Disposition in Plasma and Tissues in Mouse Models of Human Colorectal Cancer

A Pregnancy Physiologically-based Pharmacokinetic (p-PBPK) Model for Disposition of Drugs Metabolized by CYP1A2, CYP3A4, and CYP2D6

Physiologically-based Modeling of Pravastatin Transporter-mediated Hepatobiliary Disposition and Drug-drug Interactions

Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics During Pregnancy: Achievements and Shortcomings

From Pre-clinical to Human—Prediction of Oral Absorption and Drug-drug Interaction Potential Using Physiologically-based Pharmacokinetic (PBPK) Modeling Approach in an Industrial Setting: A Workflow by Using Case Example

Physiologically-based PharmacoKinetic (PBPK) Modeling Tools: How to Fit with Our Needs?

Using Simcyp to Project Human Oral Pharmacokinetic Variability in Early Drug Research to Mitigate Mechanism-based Adverse Events

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