Modeling the Influence of Ethnicity on Drug Disposition
Ever noticed how people from different ethnic backgrounds respond differently to drugs? For example, you…
Zoe Barter2015 年 11 月 23 日
Interplay of Metabolism and Transport in Determining Oral Drug Absorption and Gut Wall Metabolism: A Simulation Assessment Using the “Advanced Dissolution, Absorption, Metabolism (ADAM)” Model
Bioavailability of orally administered drugs can be influenced by a number of factors including release…
webdev2015 年 11 月 1 日
How to Optimize Your Drug Label Using Modeling and Simulation Technology
As a trained pharmacist and scientist, I think a lot about patient care and how…
Steve Toon2015 年 9 月 29 日
100 Articles That Will Help You Understand PBPK Modeling & Simulation
As a company with a strong academic foundation, our scientists actively publish the results of…
Suzanne Minton2015 年 7 月 28 日
How to Revamp Your Approach to Conventional IVIVC Models
An IVIVC (in vitro-in vivo correlation) is a predictive mathematical model describing the relationship between…
Nikunjkumar Patel2015 年 7 月 21 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part I—Digoxin Pharmacokinetic Incorporating P-glycoprotein-mediated Efflux
A prerequisite for the prediction of the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin…
webdev2013 年 9 月 1 日
Application of Permeability-limited Physiologically-based Pharmacokinetic Models: Part II—Prediction of P-glycoprotein Mediated Drug-drug Interactions with Digoxin
Digoxin is the recommended substrate for assessment of P-glycoprotein (P-gp)-mediated drug-drug interactions (DDIs) in vivo.…
webdev2013 年 9 月 1 日
Application of In Vitro-In Vivo Extrapolation (IVIVE) and Physiologically-based Pharmacokinetic Modeling to Investigate the Impact of the CYP2C8 Polymorphism on Rosiglitazone Exposure
The purpose of this study was to predict the impact of the CYP2C8*3 genotype on…
webdev2013 年 6 月 1 日
Physiologically-based Pharmacokinetic Models for Everolimus and Sorafenib in Mice
Everolimus is a mammalian target of rapamycin (mTOR) inhibitor approved as an immunosuppressant and for…
webdev2013 年 5 月 1 日
A Physiologically-based Pharmacokinetic Modeling Approach to Predict Disease-drug Interactions: Suppression of CYP3A by IL-6
Elevated cytokine levels are known to downregulate expression and suppress activity of cytochrome P450 enzymes…
webdev2013 年 4 月 10 日
