DEVELOPMENT OF A PBPK MODEL FOR EFAVIRENZ THAT ACCOUNTS FOR AUTO-INDUCTION AND ITS EFFECT ON THE CYP2B6 SUBSTRATE BUPROPION Poster DEVELOPMENT OF A PBPK MODEL FOR EFAVIRENZ THAT ACCOUNTS FOR AUTO-INDUCTION AND ITS EFFECT ON THE CYP2B6 SUBSTRATE BUPROPION webdev2019 年 8 月 23 日
Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model Poster Prediction of Midazolam Pharmacokinetics in Pregnant Women with Coeliac Disease using Simcyp Pregnancy PBPK Model webdev2019 年 8 月 23 日
Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam Poster Investigating Impacts of Model Parameters Correlations in Global Sensitivity Analysis: Determining the Most Influential Parameters of a Minimal PBPK Model of Midazolam webdev2019 年 6 月 24 日
PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions White Paper PBPK’s Pivotal Role in Modern Drug Development: Busting Common Myths and Misconceptions This white paper addresses common PBPK myths and misconceptions and demonstrates how this approach is…webdev2019 年 2 月 4 日
Using PBPK Models to Assess Fetal Drug Exposure Blog Using PBPK Models to Assess Fetal Drug Exposure The tragedy of thalidomide provides a cautionary tale about the potential for birth defects resulting…Rick Greupink2018 年 1 月 19 日
Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon Publication Application of the MechPeff Model to Predict Passive Effective Intestinal Permeability in the Different Regions of the Rodent Small Intestine and Colon webdev2017 年 2 月 1 日
Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” Publication Commentary on “In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-based Absorption Models” webdev2017 年 1 月 1 日
Assessing Drug-Smoking Interactions Using PBPK Modeling Blog Assessing Drug-Smoking Interactions Using PBPK Modeling The prevalence of cigarette smoking remains high globally despite abundant evidence showing that it isn't…Theresa Cain2016 年 7 月 29 日
Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 Publication Towards a Best Practice Approach in PBPK Modeling: Case Example of Developing a Unified Efavirenz Model Accounting for Induction of CYPs 3A4 and 2B6 webdev2016 年 7 月 20 日