Automatic differentiation, a possible solution to numerical instability in Population PK parameter estimation Poster 自动微分:群体药代动力学参数估计中数值不稳定性的可能解决方案 Danielle Pillsbury2024 年 11 月 22 日
Building Automated Pharmacometrics Analysis Workflows in R with NMsim Poster 使用 NMsim 在 R 中构建自动化药代动力学-药效学分析工作流程 Danielle Pillsbury2024 年 11 月 22 日
Population K-PD Modeling of Plozasiran (ARO-APOC3), a GalNAc-siRNA Conjugate, for the Potential Treatment of Atherosclerotic Cardiovascular Disease (ASCVD) in Patients with Mixed Hyperlipidemia Poster GalNAc-siRNA 偶联物 Plozasiran(ARO-APOC3)在混合性高脂血症患者动脉粥样硬化性心血管疾病(ASCVD)潜在治疗中的群体药代动力学-药效学(K-PD)建模 Danielle Pillsbury2024 年 11 月 22 日
Integrated Population Pharmacokinetic Model of Bemnifosbuvir and Metabolites Poster 贝米福斯布韦(Bemnifosbuvir)及其代谢物的综合群体药代动力学模型 Danielle Pillsbury2024 年 11 月 22 日
Indirect Exposure-Response Modeling for Transthyretin Amyloid Cardiomyopathy Treated with Acoramidis (AG10) Poster 转甲状腺素蛋白淀粉样变性心肌病经 Acoramidis(AG10)治疗的间接暴露-反应建模 Danielle Pillsbury2024 年 11 月 22 日
Towards Predicting Individual Cognitive Trajectories in Alzheimer’s Disease using Quantitative Systems Pharmacology Poster 运用定量系统药理学预测阿尔茨海默病患者的个体认知轨迹 About Functional readouts in Alzheimer's Disease is highly variable due to different comedications, genotypes, amyloid-…Renee Fisher2024 年 11 月 22 日
Effects of Anti-Amyloid Treatment on Tau Biomarkers and Functional Outcome Poster 抗淀粉样蛋白治疗对 Tau 生物标志物和功能结果的影响 About There are major unaddressed issues in Alzheimer's Disease clinical practice such as: Identifying accessible…Renee Fisher2024 年 11 月 22 日
A Mechanistic PK/PD Model for First-in-Human Dosing of a Tetraspecific Antibody (MDX2001) for the Treatment of Advanced Solid Tumors Poster 用于治疗晚期实体瘤的四特异性抗体(MDX2001)首次人体试验给药的机制 PK/PD 模型 MDX2001 is a tetraspecific T cell engager that binds CD3 and CD28 on T cells…Renee Fisher2024 年 11 月 22 日
Augmented Definitive Screening Design Provides Efficient Phase 1 Selection of CAR T-cell and Lymphodepletion Regimen Poster 增强型确定性筛选设计为 CAR-T 细胞和淋巴清除疗法的 1 期筛选提供了高效率 Danielle Pillsbury2024 年 11 月 22 日
Oncology MIDD Simulator, A User-Friendly Application for Overall Survival Forecasting in Early Oncology Trials Poster 肿瘤学 MIDD 模拟器 — 用于早期肿瘤学试验总生存期预测的用户友好型应用程序 Danielle Pillsbury2024 年 11 月 22 日