Model-based Development of Gemcabene, a New Lipid-altering Agent
The purpose of this study was to evaluate the value of model-based, quantitative decision making…
webdev2005 年 10 月 7 日
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model
Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…
webdev2005 年 9 月 1 日
Therapeutic Benefit of Eletriptan Compared to Sumatriptan for the Acute Relief of Migraine Pain—Results of a Model-based Meta-analysis that Accounts for Encapsulation
A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…
webdev2005 年 9 月 1 日
Modelling Approaches to Dose Estimation in Children
Most of the drugs on the market are originally developed for adults and dosage selection…
webdev2005 年 6 月 1 日
Techniques: Application of Systems Biology to Absorption, Distribution, Metabolism, Excretion, and Toxicity
It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and…
webdev2005 年 4 月 1 日
Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials
Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…
webdev2005 年 1 月 1 日
Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients
Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…
webdev2005 年 1 月 1 日
Pharmacokinetics of Dibutylphthalate in Pregnant Rats
Dibutylphthalate (DBP) can cause adverse effects on the developing male reproductive tract when administered late…
webdev2004 年 12 月 1 日
In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions
Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…
webdev2004 年 12 月 1 日
Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH
Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…
webdev2004 年 12 月 1 日
