pre-update Archives

Publication

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

The aim of this study was to model the in vivo kinetic consequences of mechanism-based…

webdev2006 年 11 月 1 日

Publication

The Impact of Experimental Design on Assessing Mechanism-based Inactivation of CYP2D6 by MDMA (Ecstasy)

MDMA (3-4-methylenedioxymethamphetamine, commonly known as Ecstasy) is a potent mechanism-based inhibitor (MBI) of cytochrome P450…

webdev2006 年 11 月 1 日

Publication

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…

webdev2006 年 9 月 1 日

Publication

Prediction of Metabolic Drug Clearance in Humans: In Vitro-In Vivo Extrapolation vs Allometric Scaling

Previously in vitro-in vivo extrapolation (IVIVE) with the Simcyp Clearance and Interaction Simulator® has been…

webdev2006 年 7 月 1 日

Publication

Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability

The Simcyp® Population-Based ADME Simulator was used to predict median drug clearances and their associated…

webdev2006 年 6 月 1 日

Publication

Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences

Potential differences in drug clearance between Japanese and Caucasians were investigated by integrating data on…

webdev2006 年 6 月 1 日

Publication

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…

webdev2006 年 5 月 1 日

Publication

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

The aim of this study was to develop a pain relief model for a cyclooxygenase…

webdev2006 年 4 月 1 日

Publication

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

A diversity of equations is available for the estimation of liver volume (LV), derived from…

webdev2005 年 12 月 1 日

Publication

Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol

The in vitro characterisation of a mechanism-based enzyme inactivator (MBEI) includes determination of the maximum…

webdev2005 年 11 月 1 日

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pre-update

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

The Impact of Experimental Design on Assessing Mechanism-based Inactivation of CYP2D6 by MDMA (Ecstasy)

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Prediction of Metabolic Drug Clearance in Humans: In Vitro-In Vivo Extrapolation vs Allometric Scaling

Prediction of In Vivo Drug Clearance from In Vitro Data, I: Impact of Inter-individual Variability

Prediction of In Vivo Drug Clearance from In Vitro Data, II: Potential Inter-ethnic Differences

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

Kinetic Values for Mechanism-based Enzyme Inhibition: Assessing the Bias Introduced by the Conventional Experimental Protocol

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