What Does Clearance Mean?
Drug clearance is an extremely important topic in the science of pharmacokinetics. Drug clearance defines…
Nathan Teuscher2010 年 6 月 13 日
Understanding Volume of Distribution
One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all…
Nathan Teuscher2010 年 6 月 5 日
Pharmacology and Safety of Glycerol Phenylbutyrate in Healthy Adults and Adults with Cirrhosis
Phenylbutyric acid (PBA), which is approved for treatment of urea cycle disorders (UCDs) as sodium…
webdev2010 年 6 月 1 日
What is Pharmacodynamics?
Starting with definitions is always helpful… so after defining pharmacokinetics, a definition for pharmacodynamics is…
Nathan Teuscher2010 年 5 月 24 日
Population Pharmacokinetic/Pharmacodynamic Model for a C.E.R.A. in Both ESA-naive and ESA-treated Chronic Kidney Disease Patients with Renal Anemia
This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model for C.E.R.A., a continuous erythropoietin…
webdev2010 年 5 月 1 日
Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease
Teduglutide is a GLP-2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's…
webdev2010 年 1 月 1 日
Clinical Trial Simulations in Pediatric Patients Using Realistic Covariates: Application to Teduglutide, a Glucagon-like Peptide-2 Analog in Neonates and Infants with Short-bowel Syndrome
Teduglutide, a synthetic glucagon-like peptide-2 (GLP-2) analog with activity relating to the regeneration, maintenance, and…
webdev2009 年 12 月 1 日
Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs
Concentration-QT (C-QT) modeling has been conducted for multiple compounds at various stages of development in…
webdev2009 年 11 月 1 日
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics
We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…
webdev2009 年 9 月 1 日
