Reference-scaled Average Bioequivalence
The standard approach for approval of generic drugs is to run a bioequivalence study to…
Certara2016 年 5 月 12 日
Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?
An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…
Venkateswari Muthukrishnan2016 年 2 月 9 日
Common Misconceptions About Computer System Validation
Drug development professionals frequently use computer systems to help them understand the pharmacokinetics (PK) and…
Debra Fontana2015 年 1 月 28 日
Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies
As a scientist at Certara and proud Dad to my three kids, pediatric drug development…
Martin Beliveau2015 年 1 月 15 日
Understanding Steady State Pharmacokinetics
“Steady state” is an important term in pharmacokinetics, but it can often seem a bit…
Nathan Teuscher2013 年 11 月 25 日
Calculating Urine PK Parameters
Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned…
Nathan Teuscher2012 年 12 月 6 日
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
Nathan Teuscher2011 年 3 月 31 日
Understanding Volume of Distribution
One of the most misunderstood pharmacokinetic (PK) parameters is volume of distribution. First of all…
Nathan Teuscher2010 年 6 月 5 日
