Model Informed Drug Development Archives

Publication

Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…

webdev2003 年 1 月 1 日

Publication

This paper presents and illustrates methodology for specifying, estimating, and evaluating a predictive model for…

webdev1999 年 12 月 1 日

Publication

Urinary drug metabolite ratios and urinary recoveries of metabolites, have been used to assess specific…

webdev1999 年 6 月 1 日

Publication

Probe substrates for various isoforms of cytochrome P450 and other drug-metabolizing enzymes are now widely…

webdev1998 年 12 月 1 日

Publication

At least six urinary metabolite ratios of caffeine have been proposed as probes for in…

webdev1996 年 4 月 1 日

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