Model Informed Drug Development Archives

Publication

Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials

Devices for neuromuscular electrical stimulation (NMES) are increasingly used by individuals without specific injuries and…

webdev2005 年 1 月 1 日

Publication

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

Olmesartan medoxomil (CS-866) is a new orally active angiotensin II receptor antagonist that is highly…

webdev2005 年 1 月 1 日

Publication

In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions

Recently, metabolic drug-drug interactions (M-DDI) have raised some high-profile problems in drug development resulting in restricted use, withdrawal…

webdev2004 年 12 月 1 日

Publication

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH

Drug/metabolite ratios (MRs) are used as in vivo markers of enzyme activity. The ratios are…

webdev2004 年 12 月 1 日

Publication

Predicting the Clearance of CYP2C9 Substrates

Recently, Andersson et al. (2004) reported that quantitative predictions of hepatic clearance from in vitro…

webdev2004 年 12 月 1 日

Publication

Cytochrome P450 3A Expression and Activity in the Human Small Intestine

Recently, von Richter et al measured the content of cytochrome P450 (CYP) 3A in paired…

webdev2004 年 10 月 1 日

Publication

Pharmacogenetics—Expectations and Reality

Thirty years have passed since Mike Rawlins, the current chairman of the National Institute for…

webdev2004 年 7 月 1 日

Publication

Prediction of Clearance from Recombinantly Expressed CYPs: Intersystem Extrapolation Factor (ISEF)

Recombinantly expressed human cytochromes P450 (rhCYPs) have been underused for the prediction of human drug…

webdev2004 年 2 月 1 日

Publication

The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain

Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…

webdev2003 年 11 月 1 日

Publication

The Effects of Dose Staggering on Metabolic Drug-drug Interactions

The purpose of this study was to investigate the effect of dose staggering on metabolic…

webdev2003 年 10 月 1 日

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模型引导的药物开发

Does Neuromuscular Electrical Stimulation Strengthen the Quadriceps Femoris? A Systematic Review of Randomized Controlled Trials

Population Pharmacokinetics of Olmesartan Following Oral Administration of Its Prodrug, Olmesartan Medoxomil: In Healthy Volunteers and Hypertensive Patients

In Silico Simulations to Assess the In Vivo Consequences of In Vitro Metabolic Drug-drug Interactions

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH

Predicting the Clearance of CYP2C9 Substrates

Cytochrome P450 3A Expression and Activity in the Human Small Intestine

Pharmacogenetics—Expectations and Reality

Prediction of Clearance from Recombinantly Expressed CYPs: Intersystem Extrapolation Factor (ISEF)

The Use of Clinical Trial Simulation to Support Dose Selection: Application to Development of a New Treatment for Chronic Neuropathic Pain

The Effects of Dose Staggering on Metabolic Drug-drug Interactions

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