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模型引导的药物开发

In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions Publication

In Vitro and In Silico Identification and Characterization of Thiabendazole as a Mechanism-based Inhibitor of CYP1A2 and Simulation of Possible Pharmacokinetic Drug-drug Interactions

Thiabendazole (TBZ) and its major metabolite 5-hydroxythiabendazole (5OH-TBZ) were screened for potential time-dependent inhibition (TDI) against CYP1A2.…
webdev
2009 年 6 月 1 日
Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding Publication

Utilization of Estimated Physicochemical Properties as an Integrated Part of Predicting Hepatic Clearance in the Early Drug-discovery Stage: Impact of Plasma and Microsomal Binding

Rapid prediction of hepatic clearance for drug candidates plays an important role for decision-making in…
webdev
2009 年 3 月 1 日
A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates Publication

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology, and Genetics: A Tale of “Bottom-up” vs. “Top-down” Recognition of Covariates

An increasing number of failures in clinical stages of drug development have been related to…
webdev
2009 年 2 月 28 日

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