Systems Pharmacology: Bridging Systems Biology and (PK/PD)
Mechanistic PKPD models are now advocated not only by academic and industrial researchers, but also…
webdev2011 年 5 月 11 日
Beyond Publication Bias
In drug development, clinical medicine, or health policy making, basing one's decisions on a selective…
webdev2011 年 5 月 1 日
The Development of UGT1A1 and 1A6 in the Pediatric Liver
UDP-glucuronosyltransferases (UGTs) are critical for the metabolism and clearance of drugs, chemicals, and hormones. The…
webdev2011 年 5 月 1 日
Towards a Better Prediction of Peak Concentration, Volume of Distribution, and Half-life After Oral Drug Administration in Man, Using Allometry
It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin…
webdev2011 年 5 月 1 日
Estimating Toxicity-related Biological Pathway Altering Doses for High-throughput Chemical Risk Assessment
We describe a framework for estimating the human dose at which a chemical significantly alters…
webdev2011 年 4 月 18 日
In Silico Prediction of Efavirenz and Rifampicin Drug-drug Interaction Considering Weight and CYP2B6 Phenotype
This study aimed to test whether a pharmacokinetic simulation model could extrapolate nonclinical drug data…
webdev2011 年 4 月 1 日
Sources of Interindividual Variability in IVIVE of Clearance: An Investigation into the Prediction of Benzodiazepine Clearance Using a Mechanistic Population-based Pharmacokinetic Model
Prediction of metabolic clearance in extreme individuals rather than the 'average human' is becoming an…
webdev2011 年 3 月 24 日
Utility of Intersystem Extrapolation Factors in Early Reaction Phenotyping and the Quantitative Extrapolation of Human Liver Microsomal Intrinsic Clearance Using Recombinant Cytochromes P450
Reaction phenotyping using recombinant human cytochromes P450 (P450) has great utility in early discovery. However,…
webdev2011 年 3 月 1 日
Casopitant: In Vitro Data and Simcyp Simulation to Predict In Vivo Metabolic Interactions Involving Cytochrome P450 3A4
has previously been shown to be a potent and selective antagonist of the human neurokinin-1…
webdev2011 年 3 月 1 日
Modeling and Predicting Drug Pharmacokinetics in Patients with Renal Impairment
Current guidance issued by the US FDA to assess the impact of renal impairment on…
webdev2011 年 3 月 1 日
