Application of IVIVE and PBPK Modeling in Prospective Prediction of Clinical Pharmacokinetics: Strategy and Approach During the Drug Discovery Phase with Four Case Studies Publication Application of IVIVE and PBPK Modeling in Prospective Prediction of Clinical Pharmacokinetics: Strategy and Approach During the Drug Discovery Phase with Four Case Studies Prospective simulations of human pharmacokinetic (PK) parameters and plasma concentration-time curves using in vitro in…webdev2012 年 3 月 1 日
Evaluation of Methods for Achieving Stable INR in Healthy Subjects During a Multiple-dose Warfarin Study Publication Evaluation of Methods for Achieving Stable INR in Healthy Subjects During a Multiple-dose Warfarin Study No consistent method is available for finding stable warfarin maintenance doses and fast stabilization of…webdev2012 年 3 月 1 日
Mechanism-based Population Modeling of the Effects of Vildagliptin on GLP-1, Glucose, and Insulin in Patients with Type 2 Diabetes Publication Mechanism-based Population Modeling of the Effects of Vildagliptin on GLP-1, Glucose, and Insulin in Patients with Type 2 Diabetes The aim of this study was to build a mechanism-based population pharmacodynamic model to describe…webdev2012 年 3 月 1 日
Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites Publication Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an…webdev2012 年 3 月 1 日
Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay! 刊物 Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay! Physiologically based pharmacokinetic (PBPK) modeling is an extremely useful approach with the ability to predict…webdev2012 年 3 月 1 日
Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir Publication Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir This study examined drug interactions between buprenorphine, a partial opioid agonist used for opioid dependence…webdev2012 年 2 月 1 日
Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats Publication Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats To determine the effect of dose, the anatomical site of injection, and the injection volume…webdev2012 年 2 月 1 日
Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S Publication Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S VEGF-C156S is a recombinant form of human vascular endothelial growth factor C (VEGF-C), which targets…webdev2012 年 2 月 1 日
Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers Publication Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers Axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1,…webdev2012 年 2 月 1 日
Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression Publication Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer.…webdev2012 年 1 月 1 日