Model Informed Drug Development Archives

Publication

Methods of Solving Rapid Binding Target-mediated Drug Disposition Model for Two Drugs Competing for the Same Receptor

The target-mediated drug disposition (TMDD) model has been adopted to describe pharmacokinetics for two drugs competing for the same receptor. A rapid binding assumption introduces total receptor and total drug concentrations while free drug concentrations C…

webdev2012 年 10 月 1 日

Publication

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

A significant barrier to realization of the full potential of clozapine as a therapeutic agent…

webdev2012 年 10 月 1 日

Publication

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

To date, there has been little investigation of the risk for drug-drug interactions involving monoclonal…

webdev2012 年 9 月 1 日

Publication

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Lesion count observed on brain magnetic resonance imaging scan is a common end point in…

webdev2012 年 9 月 1 日

Publication

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Michaelis-Menten (M-M) approximation of the target-mediated drug disposition (TMDD) pharmacokinetic (PK) model was derived…

webdev2012 年 8 月 23 日

Publication

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

The high rate of attrition during drug development and its associated high research and development…

webdev2012 年 8 月 1 日

Publication

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an…

webdev2012 年 8 月 1 日

Publication

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Overdose of & γ;-hydroxybutyrate (GHB) frequently causes respiratory depression, occasionally resulting in death; however, little…

webdev2012 年 8 月 1 日

Publication

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Vernakalant hydrochloride is a novel, predominantly atrial-selective antiarrhythmic drug that effectively and rapidly terminates atrial…

webdev2012 年 7 月 1 日

Publication

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

Sex differences in the clearance of substrates of Cytochrome P4503A (CYP3A4) have been reported frequently…

webdev2012 年 7 月 1 日

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Methods of Solving Rapid Binding Target-mediated Drug Disposition Model for Two Drugs Competing for the Same Receptor

Microdialysis Evaluation of Clozapine and N-desmethylclozapine Pharmacokinetics in Rat Brain

Pharmacokinetic mAb-mAb Interaction: Anti-VEGF mAb Decreases the Distribution of Anti-CEA mAb into Colorectal Tumor Xenografts

Dealing with Excess of Zeros in the Statistical Analysis of Magnetic Resonance Imaging Lesion Count in Multiple Sclerosis

Dose Correction for the Michaelis-Menten Approximation of the Target—Mediated Drug Disposition Model

The Right Compound in the Right Assay at the Right Time: An Integrated Discovery DMPK Strategy

Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-induced Inflammation in Rats

γ-hydroxybutyrate (GHB)-induced Respiratory Depression: Combined Receptor-transporter Inhibition Therapy for Treatment in GHB Overdose

Population Pharmacokinetics of Vernakalant Hydrochloride Injection (RSD1235) in Patients with Atrial Fibrillation or Atrial Flutter

Sex Differences in the Clearance of CYP3A4 Substrates: Exploring Possible Reasons for the Substrate Dependency and Lack of Consensus

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