Model Informed Drug Development Archives

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Animal Versus Human Oral Drug Bioavailability: Do They Correlate?

Oral bioavailability is a key consideration in development of drug products, and the use of preclinical species in predicting bioavailability in human has…

webdev2014 年 6 月 16 日

模型引导的药物开发

Model of the Distribution of Diastolic Left Ventricular Posterior Wall Thickness in Healthy Adults and Its Impact on the Behavior of a String of Virtual Cardiomyocytes

A Re-evaluation and Validation of Ontogeny Functions for CYPs 1A2 and 3A4 Based on In Vivo Data

Animal Versus Human Oral Drug Bioavailability: Do They Correlate?

Quantitative Prediction of Formulation-specific Food Effects and Their Population Variability from In Vitro Data Using the Physiologically-based ADAM Model: A Case Study Using BCS/BDDCS Class II Drug Nifedipine.

Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients

The ISoP Standards and Best Practices Committee

Model-based Meta-analysis for Quantifying Paclitaxel Dose Response in Cancer Patients

Modeling the Binding Kinetics of Bispecific Antibodies under the Framework of a Minimal Human PBPK Model

Improving the Assessment of Heart Toxicity for All New Drugs Through Translational Regulatory Science

Changes in Individual Drug-independent System Parameters during Virtual Pediatric Pharmacokinetic Trials: Introducing Time-varying Physiology into a Pediatric PBPK Model

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