Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
webdev2015 年 5 月 1 日
A Model-based Dose-response Meta-analysis of Ocular Hypotensive Agents as a Drug Development Tool to Evaluate New Therapies in Glaucoma
PURPOSE: To characterize dose and response for intraocular pressure (IOP) reduction and incidence of hyperemia…
webdev2015 年 5 月 1 日
Month 2 Culture Status and Treatment Duration as Predictors of Recurrence in Pulmonary Tuberculosis: Model Validation and Update
New regimens capable of shortening tuberculosis treatment without increasing the risk of recurrence are urgently…
webdev2015 年 4 月 29 日
Effect of Age and Sex on the Pharmacokinetics and Safety of Avibactam in Healthy Volunteers
Avibactam is a novel non-β-lactam β-lactamase inhibitor currently being assessed in combination with ceftazidime, ceftaroline…
webdev2015 年 4 月 1 日
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9
RG7652 is a fully humanized monoclonal antibody targeting human PCSK9, a regulator of serum low…
webdev2015 年 3 月 31 日
Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Avibactam Alone and in Combination with Ceftazidime in Healthy Male Volunteers: Results of Two Randomized, Placebo-controlled Studies
Avibactam is a novel non-β-lactam β-lactamase inhibitor effective against Ambler class A, C and some…
webdev2015 年 3 月 27 日
Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…
webdev2015 年 2 月 15 日
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections
Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…
webdev2015 年 2 月 1 日
Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically-based Pharmacokinetic FcRn Model
Although advantages of physiologically based pharmacokinetic models (PBPK) are now well established, PBPK models that are linked to pharmacodynamic…
webdev2015 年 1 月 5 日
Mechanistic Models Describing Active Renal Reabsorption and Secretion: A Simulation-based Study
The objective of the present study was to evaluate mechanistic pharmacokinetic models describing active renal secretion and reabsorption over a range of Michaelis-Menten parameter estimates and doses.…
webdev2015 年 1 月 1 日
