Central Nervous System (CNS) Archives

Publication

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

The purpose of this study was to compare placebo responses in neuropathic pain syndromes through systematic…

webdev2012 年 4 月 1 日

Publication

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a substrate for the ubiquitous monocarboxylate transporter…

webdev2012 年 1 月 1 日

Publication

Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever

The administration of acetaminophen via the oral and rectal routes may be contraindicated in specific…

webdev2011 年 10 月 16 日

Publication

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

A combination of general anesthesia (GA) with thoracic epidural anesthesia (TEA) may have a beneficial…

webdev2011 年 2 月 1 日

Publication

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…

webdev2011 年 1 月 1 日

Publication

A Pharmacokinetic/Pharmacodynamic Model for Cardiovascular Safety Assessment of R1551

Pharmacokinetic-pharmacodynamic relationships are crucial in understanding a drug's arrhythmogenic potential. Models assist to quantitatively relate…

webdev2010 年 8 月 21 日

Publication

In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract

Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune…

webdev2009 年 9 月 1 日

Publication

Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain

Capsaicin, a pungent compound in chili peppers, is a highly selective agonist for the transient…

webdev2009 年 8 月 1 日

Publication

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

The aim of this study was to develop a pain relief model for a cyclooxygenase…

webdev2008 年 7 月 1 日

Publication

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

webdev2007 年 9 月 1 日

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中枢神经系统（CNS）

Placebo Response Changes Depending on the Neuropathic Pain Syndrome: Results of a Systematic Review and Meta-analysis

Brain Uptake of the Drug of Abuse Gamma-hydroxybutyric Acid in Rats

Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever

Meta-analysis of Thoracic Epidural Anesthesia Versus General Anesthesia for Cardiac Surgery

The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain

A Pharmacokinetic/Pharmacodynamic Model for Cardiovascular Safety Assessment of R1551

In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract

Pharmacokinetic Analysis of Capsaicin After Topical Administration of a High-concentration Capsaicin Patch to Patients With Peripheral Neuropathic Pain

Pain Relief Model for a COX-2 Inhibitor in Patients with Postoperative Dental Pain

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

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