The Inflammatory Bowel Disease (IBD) QSP Model is based on a mechanistic multi-state mathematical model to simulate disease mechanisms and predict treatment outcomes. It provides insights into gut tissue inflammation, necroptosis, and clinically measurable biomarkers, enabling researchers to refine therapeutic strategies. By leveraging advanced modeling techniques, this platform provides clinical score predictions such as the Mayo score and Crohn’s Disease Activity Index (CDAI). The model addresses critical questions in treatment strategy, including target selection, dosage optimization, and actionable steps. Certara’s IBD model applies to a range of treatment approaches.
Inflammatory Bowel Disease (IBD) QSP Model
Predict disease activity score to personalize treatment
Learn more about the Inflammatory Bowel Disease (IBD) QSP model
Simulates Crohn’s disease and ulcerative colitis using shared biological mechanisms
Predicts clinical scores through machine-learning integration with gut markers
Guides clinical trial design with data-driven insights
Features of the IBD platform
This figure captures the full list of key biological compartments, cell types, and cytokines in the blood, gut, and lumen. It also captures the key inflammatory dynamics in the gut mucosa including the effects of the cytokines responsible for activating macrophages, dendritic cells, and neutrophils.
Outcomes
- Necroptosis
- Gut Tissue Inflammation
- Estimation of clinically measurable biomarkers
- Clinical score prediction
Diseases
- Crohn’s Disease (CD)
- Ulcerative Colitis (UC)
Treatment Strategies
- 小分子药物
- Anti-cytokine mAb
- Combination therapies
Meet the QSP experts
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专家
Douglas W. Chung
Sr Director, QSP
Douglas W. Chung is a highly experienced scientist and consultant specialized in mechanistic modeling to support drug discovery and development. His background is in biomedical engineering and focus is in quantitative systems pharmacology with over 12 years of experience consulting in biotech and pharmaceuticals. His passion is to grow the field...
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Certara offers Quantitative Systems Pharmacology (QSP) platform models across diverse therapeutic areas, enabling data-driven insights to accelerate drug development. 我们的定制化方案整合复杂生物系统，支持从研究到临床的全链条决策优化。
Speak to a QSP expert
Get in touch with our QSP experts to learn about Certara’s Inflammatory Bowel Disease (IBD) QSP Platform and how it can be applied to support treatments for CD and UC to predict disease activity score.
Predict disease activity scores with precision
Optimize treatment strategies for Crohn’s disease and ulcerative colitis
Enhance clinical trial design with data-driven insights
